65. Bradshaw K, Leipzig ND. Applications of Regenerative Tissue Engineered Scaffolds for Treatment of Spinal Cord Injury. Invited Review to Tissue Engineering. 2024. Submitted.

64. Qureshi AA, Wehrle C Ferreira-Gonzalez S, Jiao C, Hong H, Dadgar N, Jorge Arpi-Palacios, Phong YP, Kim J, Sun K, Hashimoto K, Kwon DCH, Miller C, Leipzig N, Ma WW, Melenhorst J, Aucejo F, Schlegel A. Tumor Organoids for Primary Liver Cancers: A Systematic Review of Current Applications in Diagnostics, Disease Modeling, and Drug Screening. JHEP Reports. 2024. In Press. doi:1016/j.jhepr.2024.101164

63. McClain A, Jindal A, Durr H, Puskas J, Leipzig ND. In vivo Release of Zafirlukast from Electrospun Polyisobutylene-based Fiber Mats to Reduce Capsular Contracture of Silicone Breast Prostheses. 2024. ACS Applied Bio Materials. 2024 Jul 15;7(7):4442-4453. doi: 10.1021/acsabm.4c00341.

62. Mansouri M, Lamichhane A, Das D, Aucejo F, Tavana H, Leipzig ND. Comparison of engineered liver 3D models and the role of oxygenation for patient-derived tumor cells and immortalized cell lines cocultured with tumor stroma in the detection of hepatotoxins. 2023. Advanced Biology. 2023 Oct 16:e2300386. doi: 10.1002/adbi.202300386

61. Pukale DD, Adkins-Travis K, Aryal SR, Shriver LP, Patti GJ, Leipzig ND. Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model. Fluids and Barriers of the CNS. Accepted. 2024. preprint doi: 10.21203/rs.3.rs-3243600/v1, publisher doi: 10.1186/s12987-024-00514-y

60. Abri S, Durr H, Barton HA, Adkins-Travis K, Shriver LP, Pukale DD, Fulton JA, Leipzig ND. Multifunctional Antibacterial Oxygenating Hydrogels for Managing Chronic, Infected Diabetic Wounds. 2024. Biomaterials Science . 2024. Jun 25;12(13):3458-3470. doi: 10.1039/d4b.

59. Mansouri M, Imes WD*, Roberts OS, Leipzig ND. Fabrication of oxygen carrying microparticles functionalized with liver ECM-proteins to improve phenotypic three-dimensional in vitro liver assembly, function, and responses. Biotechnology and Bioengineering. 1–14.2023. doi: 10.1002.bit.28456

58. Durr H, Leipzig ND. Advancements in Bacteriophage Therapies and Delivery for Bacterial Infection. RSC Materials Advances, 4:1249-1257, 2023. doi: 10.1039/D2MA00980C

57. Abri S, Attia R*, Leipzig ND. Modulatory contribution of oxygenating hydrogel and polyhexamethylene biguanide on the antimicrobial potency of neutrophil-like cells. 2022. ACS Biomaterials Science & Engineering. Aug 12, 2022, 8, 9, 3842–3855.  doi: 10.1021/acsbiomaterials.2c00292

56. Pukale DD, Lazarenko D, Shriver LP, Khabaz F, Leipzig ND. Osmotic contribution of synthesized betaine by choline dehydrogenase using in vivo and in vitro models of post-traumatic syringomyelia. Cellular and Molecular Bioengineering. November 22, 2022. doi: 10.1007/s12195-022-00749-5

55. Hamrangsekachaee M+, Baumann HJ+, Pukale DD, Shriver LP, Leipzig ND. Utilizing the subcutaneous foreign body response to pre-conditioned neural stem cell seeded hydrogels for application to central nervous system regeneration. 2022. ACS Applied Biomaterials. 5, 5, 2176–2184. doi: 10.1021/acsabm.2c00017

54. Singh S, Lamichhane A, Nejad PR, Heiss J, Baumann H, Gudneppanavar R, Leipzig N, Konopka M, Luker G, Tavana H. Therapeutic Targeting of Tumor-Stromal HGF-cMET Signaling in an Organotypic Triple Negative Breast Tumor Model. 2022. Molecular Cancer Research. 2022. 20 (7): 1166–1177 doi: 10.1158/1541-7786.MCR-21-0317

52. Pukale DD, Gudneppanwar R, Farrag M, Baumann HJ, Konopka M, Shriver L, Leipzig ND. Osmoregulatory role of betaine and betaine/?-aminobutyric acid transporter 1 in syringomyelia. ACS Chemical Neuroscience 2021, 12, 19, 3567–3578.   doi: 10.1021/acschemneuro.1c00056

51. Pukale DD, Farrag M, Leipzig ND. Detection of Locomotion Deficit in a Post-Traumatic Syringomyelia Rat Model Using Automated Gait Analysis Technique. Technique. PLoS ONE 16(11): e0252559. 2021. doi: 10.1371/journal.pone.0252559

50. Mansouri M, Leipzig ND. Advances in removing mass transport limitations for more physiologically relevant in vitro 3D cell constructs. Biophysics Reviews 2. 021305. 2021.  doi: 10.1063/5.004883

49. Farrag M, Pukale DD, Leipzig ND. Micro-computed tomography utility for estimation of intraparenchymal spinal cord cystic lesions in small animals. Neural Regeneration Research. 2021. Nov;16(11):2293-2298. doi: 10.4103/1673-5374.310690

48. Baumann HJ, Betonio P*, Abeywickrama C, Shriver LP⁺, Leipzig ND⁺. Metabolomic and signaling programs induced by immobilized versus soluble IFN ? in neural stem cells. Bioconjug Chem. 2020.  doi: 10.1021/acs.bioconjchem.0c00338

47. Nun N, Cruz M, Jain T, Tseng YM, Menefee J, Jatana S, Patil P, Leipzig N, McDonald C, Maytin E, Joy A. Thread Size and Polymer Composition of 3D Printed and Electrospun Wound Dressings Affect Wound Healing Outcomes in an Excisional Wound Rat Model. Biomacromolecules. Oct 12;21(10):4030-4042. doi: 10.1021/acs.biomac.0c00801

46. Patil PS, Monsouri MS, Leipzig ND. Fluorinated Chitosan Microgels to Overcome Internal Oxygen Transport Deficiencies in Microtissue Culture Systems. Advanced Biosystems. 2020. In Press. doi: 10.1002/adbi.201900250

45. Baumann HJ⁺, Mahajan G⁺, Ham TR, Betonio P^*, Kothapalli C, Shriver LP, Leipzig ND. Softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content. Journal of the Mechanical Behavior of Biomedical Materials. 2020. In Press. doi: 10.1016/j.jmbbm.2020.103953.

44. Christie SM⁺, Ham TR⁺, Gilmore GT, Toth PD, Leipzig ND⁺, Smith AW⁺. Covalently Immobilizing Interferon-? Drives Filopodia Production through Specific Receptor-Ligand Interactions Independently of Canonical Downstream Signaling. Bioconjug Chem. 2020;31(5):1362-1369. doi: 10.1021/acs.bioconjchem.0c00105

43. Ham TR, Pukale DD, Hamrangsekachaee M, Leipzig ND. Subcutaneous priming of protein-functionalized chitosan scaffolds improves function following spinal cord injury. Mater Sci Eng C Mater Biol Appl. 2020;110:110656. doi: 10.1016/j.msec.2020.110656

42. Farrag M, Abri S, Leipzig ND. pH-dependent RNA isolation from cells encapsulated in chitosan-based biomaterials. Int J Biol Macromol. 2020;146:422-430.   doi: 10.1016/j.ijbiomac.2019.12.263

41.  Abri S, Ghatpande AA, Ress J, Barton HA, Leipzig ND. Polyionic Complexed Antibacterial Heparin–Chitosan Particles for Antibiotic Deliver .” ACS Applied Biomaterials. 2019;2 (12), 5848-5858. doi: 10.1021/acsabm.9b00833

40. Ham TR, Cox DG, Leipzig ND. Concurrent Delivery of Soluble and Immobilized Proteins to Recruit and Differentiate Neural Stem Cells. Biomacromolecules. 2019; 20(9):3445-3452.doi: 10.1021/acs.biomac.9b00719

39. Patil PS, Fathollahipour S, Inmann A, Pant A, Amini R, Shriver LP, Leipzig ND. Fluorinated Methacrylamide Chitosan Hydrogel Dressings Improve Regenerated Wound Tissue Quality in Diabetic Wound Healing. Adv Wound Care (New Rochelle). 2019;8(8):374-385. doi: 10.1089/wound.2018.0887

38. Ham TR, Farrag M, Soltisz AM, Lakes EH, Allen KD, Leipzig ND. Automated Gait Analysis Detects Improvements after Intracellular Peptide Administration in a Rat Hemisection Model of Spinal Cord Injury. Ann Biomed Eng. 2019;47(3):744-753.  doi: 10.1007/s10439-019-02198-0

37. Farrag M, Leipzig ND. Subcutaneous Maturation of Neural Stem Cell-Loaded Hydrogels Forms Region-Specific Neuroepithelium. Cells. 2018;7(10):173. Published 2018 Oct 17. doi: 10.3390/cells7100173

36. Fathollahipour S, Patil PS, Leipzig ND. Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering. Cells Tissues Organs. 2018;205(5-6):350-371. doi: 10.1159/000493162

35. Patil PS, Evancho-Chapman MM, Li H, Huang H, George RL, Shriver LP, Leipzig ND. Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model. PLoS One. 2018; 13(9):e0203371. Published 2018 Sep 5. doi: 10.1371/journal.pone.0203371

34. Mohrman AE, Farrag M, Grimm RK, Leipzig ND. Evaluation of in situ gelling chitosan-PEG copolymer for use in the spinal cord. J Biomater Appl. 2018;33(3):435-446. doi: 10.1177/0885328218792824

33. Jacobs BY, Lakes EH, Reiter AJ, Lake SP, Ham TR, Leipzig ND, Porvasnik SL, Schmidt CE, Wachs RA, Allen KD. The Open Source GAITOR Suite for Rodent Gait Analysis. Sci Rep. 2018;8(1):9797. Published 2018 Jun 28.  doi: 10.1038/s41598-018-28134-1

32. Li H, Zheng J, Wang H, Becker ML, Leipzig ND. Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels. J Biomater Appl. 2018;32(9):1222-1230.  doi: 10.1177/0885328218755711

31. Ham TR, Leipzig ND. Biomaterial strategies for limiting the impact of secondary events following spinal cord injury. Biomed Mater. 2018;13(2):024105. Published 2018 Feb 8. doi: 10.1088/1748-605X/aa9bbb

30. Jindal A, Puskas JE, Nedica K, Luebbers MT, Baker JR, McClain A, Paiva dos Santos B, Camassol M, Jennings W, Einsporn RL, Leipzig ND. Encapsulation and release of Zafirlukast from electrospun polyisobutylene-based thermoplastic elastomeric fiber mat. European Polymer Journal. 98:254-261. 2018. doi: 10.1016/j.eurpolymj. 2017.11.012

29. Akula S, Brosch IK*, Leipzig ND. Fluorinated Methacrylamide Chitosan Hydrogels Enhance Cellular Wound Healing Processes. Ann Biomed Eng. 2017;45(11):2693-2702. doi: 10.1007/s10439-017-1893-6

28. Patil PS, Leipzig ND. Fluorinated methacrylamide chitosan sequesters reactive oxygen species to relieve oxidative stress while delivering oxygen. J Biomed Mater Res A. 2017;105(8):2368-2374. doi: 10.1002/jbm.a.36079

27. Ham TR, Farrag M, Leipzig ND. Covalent growth factor tethering to direct neural stem cell differentiation and self-organization. Acta Biomater. 2017;53:140-151.  doi: 10.1016/j.actbio.2017.01.068

26. Mohrman AE, Farrag M, Huang H, Ossowski S, Haft S, Shriver LP, Leipzig ND. Spinal Cord Transcriptomic and Metabolomic Analysis after Excitotoxic Injection Injury Model of Syringomyelia. J Neurotrauma. 2017;34(3):720-733.  doi: 10.1089/neu.2015.4341

25. Patil PS, Fountas-Davis N, Huang H, Michelle Evancho-Chapman M, Fulton JA, Shriver LP, Leipzig ND. Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability. Acta Biomater. 2016;36:164-174. doi: 10.1016/j.actbio.2016.03.022

24. Lawrence PG, Patil PS, Leipzig ND, Lapitsky Y. Ionically Cross-Linked Polymer Networks for the Multiple-Month Release of Small Molecules. ACS Appl Mater Interfaces. 2016;8(7):4323-4335.  doi: 10.1021/acsami.5b10070

23. Li H⁺, Ham TR⁺, Neill N^*, Farrag M, Mohrman AE, Koenig AM^*, Leipzig ND. A Hydrogel Bridge Incorporating Immobilized Growth Factors and Neural Stem/Progenitor Cells to Treat Spinal Cord Injury. Adv Healthc Mater. 2016;5(7):802-812. doi: 10.1002/adhm.201500810

22. McCormick AM, Jarmusik NA, Leipzig ND. Co-immobilization of semaphorin3A and nerve growth factor to guide and pattern axons. Acta Biomater. 2015;28:33-44.  doi: 10.1016/j.actbio.2015.09.022

21. McCormick AM, Maddipatla MV, Shi S, Chamsaz EA, Yokoyama H, Joy A⁺, Leipzig ND⁺. Micropatterned coumarin polyester thin films direct neurite orientation. ACS Appl Mater Interfaces. 2014;6(22):19655-19667.  doi: 10.1021/am5044328

20. Li H, Koenig AM, Sloan P, Leipzig ND. In vivo assessment of guided neural stem cell differentiation in growth factor immobilized chitosan-based hydrogel scaffolds. Biomaterials. 2014;35(33):9049-9057. doi: 10.1016/j.biomaterials.2014.07.038

19. Kobelt LJ*, Wilkinson AE, McCormick AM, Willits RK, Leipzig ND. Short duration electrical stimulation to enhance neurite outgrowth and maturation of adult neural stem progenitor cells. Ann Biomed Eng. 2014;42(10):2164-2176. doi: 10.1007/s10439-014-1058-9

18. Wilkinson AE, Kobelt LJ*, Leipzig ND. Immobilized ECM molecules and the effects of concentration and surface type on the control of NSC differentiation. J Biomed Mater Res A. 2014;102(10):3419-3428. doi: 10.1002/jbma.35001

17. Li H, Visco DP, Leipzig ND. Confirmation of Predicted Activity for Factor XIa Inhibitors from a Virtual High-Throughput-Screening Approach. AIChE Journal. 2014; 60(8):2741–2746.  doi: 10.1002/aic.14508

16. Li H, Wijekoon A, Leipzig ND. Encapsulated neural stem cell neuronal differentiation in fluorinated methacrylamide chitosan hydrogels. Ann Biomed Eng. 2014;42(7):1456-1469. doi: 10.1007/s10439-013-0925-0

15. McCormick AM, Jarmusik NA, Endrizzi EJ, Leipzig ND. Expression, isolation, and purification of soluble and insoluble biotinylated proteins for nerve tissue regeneration. J Vis Exp. 2014;(83):e51295. Published 2014 Jan 22. doi: 10.3791/51295

14. McCormick AM, Wijekoon A, Leipzig ND. Specific immobilization of biotinylated fusion proteins NGF and Sema3A utilizing a photo-cross-linkable diazirine compound for controlling neurite extension. Bioconjug Chem. 2013;24(9):1515-1526. doi: 10.1021/bc400058n

13. Wijekoon A, Fountas-Davis N, Leipzig ND. Fluorinated methacrylamide chitosan hydrogel systems as adaptable oxygen carriers for wound healing. Acta Biomater. 2013;9(3):5653-5664. doi: 10.1016/j.actbio.2012.10.034

12. Li H, Wijekoon A, Leipzig ND. 3D differentiation of neural stem cells in microporous photopolymerizable hydrogel scaffolds. PLoS One. 2012;7(11):e48824. doi: 10.1371/journal.pone.0048824

11. McCormick AM, Leipzig ND. Neural regenerative strategies incorporating biomolecular axon guidance signals. Ann Biomed Eng. 2012;40(3):578-597. Selected for Cover Art. doi: 10.1007/s10439-011-0505-0

10. Leipzig ND, Wylie RG, Kim H, Shoichet MS. Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds. Biomaterials. 2011;32(1):57-64. doi: 10.1016/j.biomaterials.2010.09.031

9. Leipzig ND, Shoichet MS. The effect of substrate stiffness on adult neural stem cell behavior. Biomaterials. 2009;30(36):6867-6878.  doi: 10.1016/j.biomaterials.2009.09.002

8. Leipzig ND⁺, Xu C^+*, Zahir T, Shoichet MS. Functional immobilization of interferon-gamma induces neuronal differentiation of neural stem cells. J Biomed Mater Res A. 2010;93(2):625-633. doi: 10.1002/jbm.a.32573

7. T Zahir, YF Chen, JF MacDonald, N Leipzig, CH Tator, MS Shoichet. Neural stem/progenitor cells differentiate to neurons by the combined action of dibutyryl cAMP and interferon-gamma. Stem Cells and Development. 18(10):1423-1432, 2009. doi: 10.1089/scd.2008.0412

6. Y Aizawa, Leipzig ND, T Zahir T, Shoichet MS. The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. Biomaterials. 2008; 29(35):4676-4683, 2008. doi: 10.1016/j.biomaterials.2008.08.018

5. Yu LMY, Leipzig ND, Shoichet MS. Promoting neuron adhesion and growth. Materials Today. 2008;11(5):36-43. doi: 10.1016/S1369-7021(08)70088-9

4. Leipzig ND, Athanasiou KA. Static compression of single chondrocytes catabolically modifies single-cell gene expression. Biophys J. 2008;94(6):2412-2422.  doi: 10.1529/biophysj.107.114207

3. Eleswarapu SV*, Leipzig ND, Athanasiou KA. Gene expression of single articular chondrocytes. Cell Tissue Res. 2007;327(1):43-54. doi: 10.1007/s00441-006-0258-5

2. Leipzig ND, Eleswarapu SV*, Athanasiou KA. The effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes. Osteoarthritis Cartilage. 2006;14(12):1227-1236. doi: 10.1016/j.joca.2006.05.013

1. Leipzig ND, Athanasiou KA. Unconfined creep compression of chondrocytes. J Biomech. 2005;38(1):77-85. doi: 10.1016/j.jbiomech.2004.03.013

2. AE Wilkinson, AM McCormick, ND Leipzig “Central Nervous System Tissue Engineering: Current Considerations and Strategies.” Synthesis Lectures on Tissue Engineering. KA Athanasiou and JK Leach Eds, 2011. Morgan & Claypool Publishers, p. 1-120. LINK

2. ND Leipzig, KA Athanasiou. “Cartilage regeneration.” The Encyclopedia of Biomaterials and Biomedical Engineering. G. Wnek, G. Bowlin Eds, 2008, 2nd Ed, Informa Healthcare USA Inc: New York. Vol. 1, p. 552-560.  LINK