Leipzig Bioengineering Group

Biography

I got introduced to spheroid and organoid technology by my labmate and immediately got drawn into this field! The idea of developing miniaturized versions of liver, lung, kidney, intestine, and other vital innards in the lab makes me excited! I am fascinated by and passionate about the techniques that researchers apply to alter the cellular microenvironment of spheroids/organoids. That is why my project has focused on engineering the culture condition with biomaterials to keep cells happy and functional! I aim to generate healthy and cancerous liver cell aggregates with enhanced viability and functionality for drug toxicity screening. Besides research, I love to travel, do things I’ve never done before, meet new people, eat different kinds of food, and experience different cultures.

Education

B. Tech. in Biomedical Engineering, Science and Research University, Sep 2012, Tehran, Iran.

M. Tech. in Biomedical Engineering, Amirkabir University of Technology, Sep 2015, Tehran, Iran.

Publications/Book Chapters

1. Mansouri M, Imes WD*, Roberts OS, Leipzig ND. Fabrication of oxygen carrying microparticles functionalized with liver ECM-proteins to improve phenotypic three-dimensional in vitro liver assembly, function, and responses. Biotechnology and Bioengineering. 2023. In Press. doi: 10.1002.bit.28456
2. Mansouri M, Beemer, S., Kothapalli, C. R., Rhoades, T., Fodor, P. S., Das, D., & Leipzig, N. D (2022).  Generation of Oxygenating Fluorinated Methacrylamide Chitosan Microparticles to Increase Cell Survival and Function in Large Liver Spheroids. ACS Applied Materials and Interfaces. 14(4).
3. Mansouri M , Leipzig ND. Advances in removing mass transport limitations for more physiologically relevant in vitro 3D cell constructs (2021). Biophysics Reviews 2. 021305
4. Patil, P. S., Mansouri, M., & Leipzig, N. D. (2020). Fluorinated Chitosan Microgels to Overcome Internal Oxygen Transport Deficiencies in Microtissue Culture Systems. Advanced Biosystems, 4(8), 1900250.
5. Oustadi, F., Haghbin Nazarpak, M., Mansouri, M., & Ketabat, F. (2020). Preparation, characterization, and drug release study of ibuprofen-loaded poly (vinyl alcohol)/poly (vinyl pyrrolidone) bilayer antibacterial membrane. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-10.
6. Nourmohammadi, J., Hadidi, M., Nazarpak, M. H., Mansouri, M., & Hasannasab, M. (2020). Physicochemical and antibacterial characterization of nanofibrous wound dressing from silk fibroin-polyvinyl alcohol-elaeagnus angustifolia extract. Fibers and Polymers, 21(3), 456-464
7. Mansouri M , Nazarpak MH, Solouk A, Akbari S, Hasani-Sadrabadi MM. “Magnetic responsive of paclitaxel delivery system based on SPION and palmitoyl chitosan”. Journal of Magnetism and Magnetic Materials 421 (2017): 316-325.

Conference Papers

1. Mansouri M, Imes, W*, Leipzig ND. ECM protein-decorated microparticles to maintain cell survival and liver-specific function. Society for Biomaterials 2022 Annual Meeting and Exposition. April 27-30 Baltimore, MD. Oral Presentation.
2. M Mansouri, N Leipzig.  “Regulation of the Liver Spheroid Microenvironment Using Engineered Oxygenating Microparticles”. BMES Annual Meeting, October 14-17, 2020. Poster and short video.